23 Jul Application of rehmannioside C and salvianolic acid A in promoting proliferation of bone marrow mesenchymal stem cells cultured in vitro and inhibiting replicative senescence
Abstract
The invention discloses an application of rehmannioside C and salvianolic acid A in promoting proliferation of bone marrow mesenchymal stem cells cultured in vitro and inhibiting replicative senescence. The rehmannioside C and the salvianolic acid A coexist. The rehmannioside C and the salvianolic acid A has the functions of promoting the proliferation of the bone marrow mesenchymal stem cells cultured in vitro and inhibiting the replicative senescence, and provide enough stem cells for clinical treatment. The rehmannioside C and the salvianolic acid A are commercially available high-purity rehmannioside C and the salvianolic acid A (with the content being greater than or equal to 98%) or can be prepared according to a conventional method. The advantages of the rehmannioside C and the salvianolic acid A are that the rehmannioside C and the salvianolic acid A can promote the proliferation of the bone marrow mesenchymal stem cells and inhibit the replicative senescence, provide sufficient cells for tissue engineering for treatment of bone defects, cartilage defects, liver fibrosis, myocardial infarction, pulmonary fibrosis, diabetes and the like and stem cell therapy, and reduce bodyimmune rejection.
Year: 2018
Country: CN
Doc No: 108949677