23 Jul Application of oncostatin M in preparation of products for promoting mesenchymal stem cells to be in vitro directionally differentiated into bone cells
Abstract
The invention belongs to the technical field of cell biotechnology and bone tissue engineering, and particularly relates to application of oncostatin M in preparation of products for promoting mesenchymal stem cells to be in vitro directionally differentiated into bone cells. Experiments prove that oncostatin M has functions of increasing expression of formed bone differentiation markers ALP, Runx2, OPN and OCN in mRNA and protein level and promoting the mesenchymal stem cells to be differentiated directionally into the bone cells. Application studying of oncostatin M matched with the mesenchymal stem cells in preparation of drugs for treating bone injury provides a material basis for development and preparation of drugs for treating diseases like osteoporosis, fracture bone loss and bone trauma.
Year: 2016
Country: CN
Doc No: 106119190