23 Jul Application of long-chain non-coding RNA lnc-HCAR in preparation of bone repair system and bone repair system and preparation method thereof
Abstract
The invention discloses application of long-chain non-coding RNA lnc-HCAR in preparation of bone repair system based on endochondral osteogenesis. The nucleotide sequence of the lnc-HCAR is SEQ ID NO.As shown in Fig. 1, the lnc-HCAR can promote the expression of Vegfa gene and Mmp13 gene, and can competitively bind to miR-15b-5p, thereby promoting hypertrophy of chondrocytes, promoting blood vessel formation in cartilage osteogenesis, and promoting Remodeling of the matrix in the cartilage osteogenesis. The bone repair system based on the long-chain non-coding RNA lnc-HCAR includes lnc-HCAR,gene delivery system, mesenchymal stem cells and porous bone scaffold materials. The invention has good application prospects in tissue engineering bone construction and bone defect repair.
Year: 2019
Country: CN
Doc No: 109224130