23 Jul Application of chemical small molecule 4-aminobiphenyl in prevention and treatment of osteoarthritis
Abstract
The invention discloses an application of 4-aminobiphenyl (4-ABP) as a small molecule compound in treatment of osteoarthritis. The experiments show that topical application of 4-ABP can effectively repair cartilage damage caused by DMM in mice, increases the expression level of Collagen II, CD44, and CD105 protein, reduces the expression of Collagen X, and increases the thickness of cartilage andthe expression of a cartilage matrix. Therefore, the application proves that 4-ABP can effectively reduce cartilage damage during osteoarthritis and delay cartilage degeneration. The application of the 4-aminobiphenyl (4-ABP) small molecule compound provided by the invention in the treatment of osteoarthritis can provide a new solution for promoting damage cartilage regeneration for medical research and tissue engineering research. The application also includes the therapeutic effect of a tablet containing 4-ABP, an injection, a powder injection, and the like on cartilage degeneration and damage such as osteoarthritis.
Year: 2019
Country: CN
Doc No: 110403925