23 Jul Application of carbonate polymer containing bi-sulfur five-member ring functional gene in side chain
Abstract
The invention discloses application of a carbonate polymer containing a bi-sulfur five-member ring functional gene in a side chain. The polymer is obtained through activity-controllable ring-opening polymerization based on a cyclic carbonate monomer containing the bi-sulfur five-member ring functional gene; the polymer is controllable in molecular wight, relatively narrow in molecular weight distribution and free from protection and deprotection processes; the polymer obtained from the cyclic carbonate monomer through ring-opening polymerization is biodegradable and is suitable for controlling a drug release system; a prepared tumor-targeted reduction-sensitive reversible cross-linking nano-drug carrier supports in vivo long circulation, but the nano-drug carrier can be rapidly de-cross-linked to release drugs in cells highly enriched with cancer cells, so that the cancer kills can be killed with high specificity. Meanwhile, the carbonate polymer has application prospect in such aspects as tissue engineering scaffolds, biochip coatings and the like.
Year: 2016
Country: CN
Doc No: 105770900