23 Jul Application of basic fibroblast growth factor to improvement of tissue engineered heart conduction bundle deformation
Abstract
The invention relates to the technical field of biomedical engineering. The inventor builds a tissue engineered conduction bundle which consists of an embryonic heart progenitor cell and a collagen sponge stent and has very high compatibility. As proved by in-vitro researches, the built tissue engineered conduction bundle tends to undergo contraction deformation, and an initially-designed stent material form cannot be maintained accurately. The invention aims to find a method for solving the problem of deformation of a built cell stent compound. The invention provides application of a basic fibroblast (bFGF) growth factor to improvement of tissue engineered heart conduction bundle deformation. A basic fibroblast growth factor is added into a culture fluid of a tissue engineered heat conduction bundle, so that the problem of deformation of the tissue engineered heart conduction bundle is improved, a tissue engineered heart conduction bundle which can keep a better original shape in vitro and has electrocardio-conduction property is obtained, and a basis is laid for the treatment of an arrhythmi disease caused by atrioventricular conduction stagnation.
Year: 2012
Country: CN
Doc No: 102755666