23 Jul ANTISENSE COMPOUNDS TARGETED TO CONNEXINS AND METHODS OF USE THEREOF
Abstract
PROBLEM TO BE SOLVED: To provide a compound (including an antisense compound) useful for tissue engineering.SOLUTION: Provided are methods and compositions for modulating the activities of connexins (for example, for use in post-surgical trauma or tissue engineering applications). These compounds and methods can be used therapeutically, for example, to reduce the severity of adverse effects associated diseases and disorders where localized disruption in direct-cell to cell communication is desirable. Further provided is a method for reducing tissue damage associated with an ophthalmic procedure in a subject, comprising administering an antisense compound to the eye of said subject in conjunction with said procedure in an amount sufficient to inhibit the expression of a connexin protein in the eye or in cells associated with the eye of said subject.
Year: 2014
Country: JP
Doc No: 2014122248