23 Jul ANTISENSE COMPOUND TARGETED TO CONNEXIN AND METHOD OF USE THEREOF
Abstract
PROBLEM TO BE SOLVED: To provide compounds (including antisense compounds) useful in tissue engineering.SOLUTION: A method and composition for modulating the activities of connexins are provided (for example, including the use in post-surgical trauma or tissue engineering application). These compounds and methods can be used therapeutically, for example, to reduce the severity of adverse effects associated diseases and disorders where localized disruption in direct cell-cell communication is desirable. A method for reducing tissue damage is associated with an ophthalmic procedure in a subject, comprising administering an antisense compound to the eye of the subject in conjunction with the procedure in an amount sufficient to modulate the expression of a connexin protein in the eye or in cells associated with the eye of the subject.
Year: 2011
Country: JP
Doc No: 2011201926