23 Jul Alkoxyether dendrimer/gelatin composite cryogel, preparation method and applications thereof
Abstract
The invention relates to an alkoxyether dendrimer/gelatin composite cryogel, a preparation method and applications thereof. According to the present invention, a series of intelligent hydrogels with characteristics of moderate mechanical properties, oriented porous structure and temperature response are prepared by using gelatin modified with methacrylic anhydride and alkoxyether dendron with excellent temperature sensitive behavior as raw materials and by adopting a redox reaction through a one-way freezing method, wherein the pore size and the mechanical properties of the gel can be adjustedby regulating the ratio of different components and the cooling rate; the method is simple, safe and effective, and does not use organic solutions; the results of cell culture show that the gel has good adhesion to cells, the cells have high survival rate, and the growth morphology of the cells is controlled by the pore size and the morphology of the gel; and the obtained hydrogel can be used forthe simulation of cell matrixes, and can further be used in other tissue engineering and drug controlled release.
Year: 2019
Country: CN
Doc No: 110183595