23 Jul Alginate complex gel stent material constructed based on homogeneous phase crosslinking and layer-by-layer self-assembly technology and preparation method thereof
Abstract
The invention relates to a gel material, in particular to an alginate complex gel stent material constructed based on homogeneous phase crosslinking and layer-by-layer self-assembly technology and a preparation method thereof, and belongs to the technical field of tissue engineering. Alginate gel is prepared with an HAP/GDL compound as an endogenous crosslinking agent, wherein the mole ratio of HAP to GDL is 1:10, and meanwhile, it is determined that the mole ratio of the Ca element in the HAP to -COOH in sodium alginate (SA) is 0.18-0.36; afterwards, chitosan (CS) with positive electricity and B-type gelatin (GT) (collagen or sericin) with negative electricity are alternately deposited on the surface of the alginate gel through the electrostatic effect; and finally, the GT (collagen or sericin) on the outermost layer is subjected to covalent crosslinking through an EDC/NHS mixture, and therefore an alginate complex gel stent with homogeneous phase crosslinking is prepared.
Year: 2019
Country: CN
Doc No: 110302427