23 Jul ADHESIVE EXTRACELLULAR MATRIX MIMETIC
Abstract
An extracellular matrix mimetic comprising a hydrogel which is formed by crosslinking a recombinant mussel adhesive protein and a bio-polymer is provided. The three dimensional hydrogel matrix provides biochemical and biophysical microenvironments similar to native extracellular matrix and thus is capable of supporting cell in-growth in vivo or in vitro. The matrix can be tailored to further comprise one or more bioactive peptides. The matrix may also comprise cells encapsulated and dispersed therein, which are capable of proliferating or differentiating upon deposition of the matrix in vivo or in vitro. Methods of preparing the adhesive extracellular matrix and the use of the matrix in vivo or in vitro for tissue engineering or drug delivery applications are also provided.
Year: 2011
Country: WO
Doc No: 2011115420