23 Jul Active microspheres capable of directionally regulating and controlling chondrocyte accumulation and preparation method of active microspheres
Abstract
The invention provides a porous microsphere bracket material capable of regulating and controlling the directionally-accumulation biological activity of chondrocytes and a preparation method of the porous microsphere bracket material. The preparation method can be applied to preparation of substitutes for chondrocyte accumulation in a embryonic development process and in a clinical cartilage defect recovery process, and can be applied to the construction of biological active bracket materials in the fields of cartilage tissue recovery and the like. According to the method, active porous microspheres are prepared in the following steps of preparation of porous polyester high-molecule microspheres, chemical crosslinking and drying. The microspheres obtained by the method are high in biocompatibility and degradability and rational in physicochemical property and in microscopic topology morphology, and have porous structures with excellent connectivity and biological activity factor concentration gradient from inside to outside, thus being capable of regulating and controlling the directional chondrocyte accumulation in vitro, providing a good carrier for the in-vitro function expression of the chondrocytes, and serving as a good biological bracket material for tissue engineering cartilage.
Year: 2012
Country: CN
Doc No: 102690436