23 Jul Active artificial cornea and preparation method thereof
Abstract
The invention discloses an active artificial cornea and a preparation method thereof. The artificial cornea has a one-piece synthetic high-molecular polymer hydrogel structure containing gradient components, and is prepared from a biological inactive central optical part and a biological active peripheral part. According to the preparation method, a substrate, which is optically transparent in the center and has gradient hydrogel properties at the periphery, of the artificial cornea is prepared; the central parts (inner face and outer face) of the substrate of the artificial cornea are coated with polyvinylidene fluoride, tetrafluoromethane and heptafluoropropane by using a nano-coating technology and are then subjected to plasma treatment, so that inert surfaces are formed; after that, collagen grafting as well as small molecule peptide and growth factor induced activation are carried out on the periphery of the substrate, so that the biological activity and tissue engineering of the substrate are realized; finally, the active artificial cornea which is excellent in center optical properties, good in peripheral biocompatibility, simple in structure and convenient for operation and can stably exist for a long time without prolapsing can be obtained. Perforated hole structures are made at the periphery of the artificial cornea, so that the artificial cornea is facilitated to be closely jointed with the eyes of a patient.
Year: 2017
Country: CN
Doc No: 107007879