23 Jul Accurate printing construction method for liver unit chip containing acinus three-vessel structure
Abstract
The invention discloses an accurate printing construction method for a liver unit chip containing an acinus three-vessel structure, and belongs to the field of microfluidic technologies, tissue engineering and biological three-dimensional (3D) printing. According to the method, hydrogel containing cells constructs a liver tissue model in a microfluidic chip through a biological 3D printer, and theliver cell hydrogel model is subjected to perfusion culture through structural design of the microfluidic chip to simulate the liver microenvironment of a human body; and the chip comprises multiplelayers and contains three types of different micro-channel structures so as to reproduce a three-vessel system of the hepatic arteries, portal veins and central veins in liver lobules. The accurate printing construction method provides a more accurate analytical testing platform for drug development and liver drug toxicity testing.
Year: 2019
Country: CN
Doc No: 110551679