23 Jul METHOD OF PRODUCING A COLLAGEN LAYER
Abstract
The present invention relates to a method of producing a collagen layer comprising (a) introducing into a first solution located on a surface by applying a hydrodynamic flow a second solution containing solubilized collagen. It is preferred that the introduction is effected by injection or by guided directed flow. In another preferred embodiment of the invention, the method further comprises the step of (b) re-aligning the collagen fibers formed in step (a). Re-alignment may advantageously be effected mechanically by the stylus of an AFM microscope. The present invention also relates to a collagen layer producable or produced by the method of the invention and to various uses of said collagen layer including in processes of biomineralisation, cell attachment, cell motility and migration, tissue engineering, coating of implants and directed wound healing.
Year: 2004
Country: WO
Doc No: 2004071546