23 Jul Method for preparing injectable polyletic acid micro-carrier/chitosan hydrogel composite scaffold
Abstract
The invention discloses a method for preparing injection polylactic acid microcarrier/ chitose aqueous gel composite cradle, grafting the methacrylic acid and lactic acid onto the chitose molecular chain in order with carbodiimide condensation method, and getting the polymerized water soluble chitose derivative, mixing the polylactic acid microcarrier and chitose aqueous gel, adding thickening agent konjak glucomannan to increase the viscosity of the prepolymer solution to guarantee the polylactic acid microcarrier suspension, which is facilitate for the injection operation, employing the redox initiating system of ammonium peroxodisulfate and tetramethylethylenediamine to make the composite mentioned above gelify to composite cradle of cell microcarrier/ chitose aqueous gel under body temperature in home position. The process of this invention is simple, the prepared composite cradle not only solves the problems of uneasy to shape and mobile of the injection microcarrier in the body, but also can distinctively increase the aqueous gel intensity. The composite cradle is non toxic, biodegradable and biological compatibility, and is expected to be used for injection cradle in tissue engineering.
Year: 2006
Country: CN
Doc No: 1799644