23 Jul BIOABSORBABLE AND BIOCOMPATIBLE POLYURETHANES AND POLYAMIDES FOR MEDICAL DEVICES
Abstract
Absorbable polyurethanes, polyamides and polyester urethanes prepared from at least one compound selected from: Rn .COO-(X)P-R’ Rn O-(X)p-R’ W. .O- (X)p-R’ OCN Rn Rn NH-(Y)P-R’ ,,COO-(X)P-R’ V^. ^0-(Y)P-R1 OCN H2N or the diamines and diisocyanates thereof, wherein each X represents a member independently selected from -CH2COO- (glycolic acid moiety), -CH(CH3)COO- (lactic acid moiety), -CH2CH2OCH2COO- (dioxanone), -CH2CH2CH2CH2CH2COO- (caprolactone moiety), -(CH2)yCOO- where y is one of the numbers 2, 3, 4 or 6- 24 inclusive, and -( CH2CH2O)Z CH2COO- where z’ is an integer between 2 and 24, inclusive; each Y represents a member independently selected from -COCH2O- (glycolic ester moiety), -COCH(CH3)O- (lactic ester moiety), -COCH2OCH2CH2O- (dioxanone ester), -COCH2CH2CH2CH2CH2O- (caprolactone ester), -CO(CH2)mO- where m is an integer between 2, 3, 4 or 6 – 24 inclusive, -COCH2O(CH2CH2O)n- where n is an integer between 2 and 24, inclusive; R’ is hydrogen, benzyl or an alkyl group, the alkyl group being either straight-chained or branched; p is an integer between 1 and 4, inclusive; and Rn represents one or more members selected from H, alkoxy, benzyloxy, aldehyde, halogen, carboxylic acid and -NO2, which is attached directly to an aromatic ring or attached through an aliphatic chain. Absorbable poly¬ mers prepared from these compounds are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention and other implantable medical devices.
Year: 2007
Country: WO
Doc No: 2007030464