23 Jul Product for treating myocardial infarction based on chitosan aquagel and growth factor
Abstract
The invention discloses an injectable myocardial tissue engineering product based on temperature-sensitive chitosan aquagel. Concretely, the temperature-sensitive chitosan aquagel is used as a support material and carries one or a plurality of different blood vessel growth promotion factors, such as bFGF, PDGF-BB, VEGF, and the like, and the condition that the temperature-sensitive chitosan aquagel restores a myocardial infarction area is observed after the temperature-sensitive chitosan aquagel is injected and transplanted to the specific area of an animal myocardial infarction model. The temperature-sensitive myocardial tissue engineering product established by applying the support material can promote the growth of myocardial capillary vessels and arteriolae, can increase the growth of sarcogenic fibres, can promote the regeneration of myocardial tissues, can increase the locular wall thickness of the infarction area, can remodel the shape of an original ventricle and can improve the function of the heart. The invention has simple operation technology and mild enforcement condition, provides a new product for the myocardial tissue engineering and has an important meaning for the clinical development of treating heart diseases to tissue engineering cardiac muscles.
Year: 2009
Country: CN
Doc No: 101574514