23 Jul Chitosan quaternary phosphonium salt derivative and preparation method thereof
Abstract
The invention relates to a chitosan quaternary phosphonium salt derivative in the technical field of antibacterial medicaments and a preparation method thereof. The preparation method comprises the following steps: dissolving chitosan in acetic acid aqueous solution to prepare chitosan-acetate solution; adding lauryl sodium sulfate aqueous solution into the chitosan-acetate solution for complex process to prepare CS-SDS; dissolving CS-SDS in NMP, then adding micro-molecular quaternary phosphonium salt, EDC and HoBt in sequence in a nitrogen atmosphere, precipitating after agitating reaction via organic solvent to generate CS-SDS-P; dissolving CS-SDD-P by dimethyl sulfoxide, carrying out dialyzing and condensing process, and finally freeze-drying to prepare the chitosan quaternary phosphonium salt derivative. Compared with Chitosan quaternary ammonium salt, the chitosan quaternary phosphonium salt derivative prepared by the invention has stronger bacteriostatic sterilization ability andimproves the biocompatibility simultaneously. As a novel antibacterial material, the chitosan quaternary phosphonium salt derivative can be applied widely to the fields of tissue engineering, biochemical and the like.
Year: 2010
Country: CN
Doc No: 101649007