23 Jul Hydroxyl telechelic polyester material based on piperazine block and preparation method thereof
Abstract
The invention relates to a hydroxyl telechelic polyester material based on piperazine block and a preparation method thereof. Piperazine serves as an assistant initiator, and stannous octoate serves as an initiator; at the temperature of 130-170 DEG C, an annular esters monomer (annular diester such as lactide, glycolide, epsilon-caprolactone, ixoxanone and the like or lactone) is initiated for fusion and ring-opening polymerization to obtain the hydroxyl telechelic polyester material. The main chain of the hydroxyl telechelic polyester material based on the piperazine block of the invention is inserted with piperazine micromolecule rigid rings, and the mechanical property of the material is correspondingly improved; piperzaine is a common drug intermediate, has a certain bioactivity and can fill up the deficiency of insufficient polyester material activity; meanwhile, the molar ratio of the piperaztine and the annular esters monomer is controlled to control the molecular weight of the polyester material, so that the hydroxyl telechelic polyester material is convenient to apply in different areas; in addition, the polyester has biodegradability and favourable biocompatibility, has important application value on the aspect of drug slow release carriers and tissue engineering biological materials and can serve as the ultra high molecular weight polymers or the prepolymers of the polyester biological materials.
Year: 2010
Country: CN
Doc No: 101899146