23 Jul Biomaterial comprising collagen and a calcium phosphate material
Abstract
Disclosed is a process for the preparation of a composite biomaterial comprising collagen and a calcium phosphate material, or collagen, a calcium phosphate material and a glycosaminoglycan, the process comprising: (a) providing a first slurry which has a liquid carrier, collagen, a calcium phosphate material and optionally a glycosaminoglycan and a second slurry composition comprising a liquid carrier, collagen, and optionally a calcium phosphate material and optionally a glycosaminoglycan; (b) providing a mould for the slurry; (c) depositing the first and second slurries in the mould; (d) cooling the slurry deposited in the mould to a temperature at which the liquid carrier transforms into a plurality of solid crystals or particles; (e) removing at least some of the plurality of solid crystals or particles by sublimation and/or evaporation to leave a porous composite material comprising collagen, a calcium phosphate material, and optionally a glycosaminoglycan; and (f) removing the material from the mould. Also disclosed is the biomaterial made from the process with can be used for repairing interfaces between tissues and a synthetic bone material, bone implant, bone graft, bone substitute, bone scaffold, filler, coating or cement comprising the biomaterial and a layered bone scaffold comprising the biomaterial used in tissue engineering.
Year: 2010
Country: NZ
Doc No: 561209