23 Jul Surface modification method of aliphatic polyester electrospun fiber by using sodium alginate and gelatin
Abstract
The invention provides a surface modification method of aliphatic polyester electrospun fiber by using sodium alginate and gelatin. The method comprises the following steps: dissolving aliphatic polyester to obtain aliphatic polyester spinning solution; electro-spinning the aliphatic polyester spinning solution to obtain aliphatic polyester superfine fibrous membrane; collecting and drying the aliphatic polyester superfine fibrous membrane; soaking the dried membrane in dilution solvent; soaking in sodium alginate solution; soaking in cross-linking agent aqueous solution at low temperature; and soaking in gelatin solution at low temperature. The surface modification method has the beneficial effects that the sodium alginate is fixed on the surface of the aliphatic polyester electrospun fiber by a physical method, and then the gelatin is covalently bonded with the sodium alginate by a chemical crosslinking method so as to obtain an aliphatic polyester electrospun fiber tissue engineering frame with double-layer natural macromolecular coatings, thus the obtained tissue engineering frame has the advantages of mechanical properties of aliphatic polyester as well as cellular affinity of natural macromolecules. The surface modification method is simple and convenient, and has wide application prospect in tissue engineering.
Year: 2011
Country: CN
Doc No: 102251393