23 Jul Method for fixing functional molecules on biomedical material surface with dopamine serving as bridging
Abstract
The invention discloses a method for fixing functional molecules on a biomedical material surface with dopamine serving as a bridging. The method uses the dopamine to serve as a bridging medium, firstly uses strong auto polymerization characters of the dopamine under certain pH environment to be assembled on the biomedical material surface to form a poly-dopamine layer, and then a chemical reaction is used for stem grafting of the functional molecules on the poly-dopamine layer to build the biomedical material surface with biological activity. The method does not damage the biological activity of the functional molecules and can change assembling thickness of the poly-dopamine layer by controlling reaction time so as to change grafting percent of the functional molecules on the surface. The method is simple and practical in process, good in repeatability and capable of widely applying to surface functionalization modification of biomedical materials such as intervention materials and tissue engineering materials, and has good clinical application prospects.
Year: 2012
Country: CN
Doc No: 102813963