23 Jul Polyglutamic acid derivative as well as hydrogel and preparation method of polyglutamic acid derivative
Abstract
The invention discloses a polyglutamic acid derivative as well as a hydrogel and a preparation method of the polyglutamic acid derivative. The structure formula of the polyglutamic acid derivative is shown in a formula (I), wherein n is any integer of 20-60. During the preparation, isopropamide is successfully introduced into a methoxy polyethylene glycol-b-polyglutamic acid block copolymer through a simple chemical modification method and a biodegradable hydrogel material with a certain mechanical strength is successfully prepared. The mechanical property of the hydrogel material can be changed by controllably changing the length of the polymer chain segment, so that the polyglutamic acid derivative and the hydrogel disclosed by the invention can be widely applied to the fields of medicine carriers, tissue engineering scaffolds and the like.
Year: 2013
Country: CN
Doc No: 103113579