23 Jul Phosphorite hollow microsphere and preparation method thereof
Abstract
The invention discloses a phosphorite hollow microsphere and a preparation method thereof. The preparation method comprises the following steps of incubating a yeast cell into yeast extract powder peptone dextrose culture medium containing 0-10mg/ml of strontium salt to shake and cultivate for 1-3 days, obtaining the gathered yeast cell after centrifugal purification; obtaining a self-assembled biological template from the yeast cell by a layer-by-layer self-assembling technology; soaking the biological template into mixed solution of which the molar ratio of calcium salt to the strontium salt is as follows: Sr/(Ca+Sr)=0-15%; continuously agitating, and obtaining the biological template of adsorbing metal ions after separation; soaking the biological template into phosphorus salt solution; adjusting the pH value to agitate, separating and drying to obtain the composite microsphere; carrying out heat preservation on the composite microsphere for 1-6 hours at 100-900 DEG C to obtain the phosphorite hollow microsphere. The microsphere has a porous hollow structure and good cell compatibility, and can be prepared into a drug carrier or a human tissue engineering bracket and applied to the field of medical treatment of bone tissue defect.
Year: 2013
Country: CN
Doc No: 103120921