23 Jul Preparation method of alginate hybrid hydrogel film and grafting material of immobilized bio-macromolecule
Abstract
The invention provides a preparation method of an alginate hybrid hydrogel film and a grafting material of an immobilized bio-macromolecule. The preparation method comprises the following steps of: introducing other substances capable of reacting with a metal ion cross-linking agent in a process of preparing alginate hybrid hydrogel; fixing the bio-macromolecule to the thickness-adjustable hybrid hydrogel film by adsorbing, embedding or covalent bond cross-linking after adsorbing and embedding; and grafting the alginate hybrid hydrogel film to surfaces of other substrate materials by virtue of an ion cross-linking way to obtain the alginate hybrid hydrogel film grafting material of the immobilized bio-macromolecule. The preparation method disclosed by the invention is simple and free of any organic solvent; the immobilized bio-macromolecule is high in activity, good in material self-biocompatibility, controllable in membrane thickness, capable of grafting to carriers of various shapes, and good in application prospects in the fields including tissue engineering, drug control release, catalysis and the like.
Year: 2013
Country: CN
Doc No: 103232989