23 Jul TGF-Beta3 (Transforming Growth Factor Beta3) loaded slow-release tissue engineering synovial sheath
Abstract
The invention discloses a TGF-Beta3 (Transforming Growth Factor Beta3) loaded slow-release tissue engineering synovial sheath. The synovial sheath is characterized by consisting of a dense layer (1) and a porous layer (2), wherein the porous layer (2) is mesh-shaped, and chitosan microspheres containing TGF-Beta3 and synovial cells are loaded into the porous layer (2). According to the synovial sheath, the artificial synovialization of chitosan scaffolds is realized. The TGF-Beta3 loaded slow-release tissue engineering synovial sheath has the advantages that the slow release of the TGF-Beta3 can be realized, the cicatrization resisting effect of the TGF-Beta3 is exerted, the TGF-Beta3 with biological activity is released in a slow and sustained manner, and active substances, such as hyaluronic acid and the like, secreted by synovial survival cells can be utilized so as to be expected to play a role in adhesion prevention after tendon injury repair. The synovial sheath can serve as an ideal material for preventing adhesion after tendon injury repair, and has good preventing and treating effects when the synovial sheath is applied to tendon adhesion in orthopedics.
Year: 2013
Country: CN
Doc No: 103239759