23 Jul Method for preparing tissue engineering scaffold with double-pore structure by combining with supercritical carbon dioxide foaming technology
Abstract
The invention discloses a method for preparing a tissue engineering scaffold with a double-pore structure by combining with a supercritical carbon dioxide foaming technology. The method comprises the following steps: physically mixing a commercial pore-foaming agent and polymer powder and tabletting; putting the matrix in a high-pressure autoclave, maintaining the pressure in supercritical carbon dioxide for a period of time, and performing quick pressure relief, so that lots of foaming cores are generated in the polymer substrate and the complex grows to generate a foaming hole; and finally, eluting the pore-foaming agent granules to form the multi-pore scaffold which is communicated with each other and has a double-pore structure. The method has the characteristics of mild operating conditions, simple operation process and stable process, an organic solvent is not used in the scaffold preparation process, and the method can be applied to preparing the multi-pore tissue engineering scaffold.
Year: 2013
Country: CN
Doc No: 103254459