23 Jul MULTIFUNCTIONAL TUNABLE BIOMATERIALS FOR TISSUE ENGINEERING
Abstract
The present invention provides a multifunctional biomaterial comprising one or more biocompatible polymers and one or more alpha-cyclodextrin molecules having a plurality of hydroxyl groups capable of being chemically substituted with another functional group or moiety to form a pseudopolyrotaxane structure. The multifunctional biomaterials of the present invention provide synthetic 2D or 3D biomaterial scaffolds and nanofibers that can be decorated with multiple chemical functionalities without altering the base network. The polymer chains can be crosslinked via the terminal ends of the polymers and not through the alpha-cyclodextrin molecules. The inventive technology is useful for engineering tissue with human stem cells, including, mesenchymal stem cells (hMSCs) and adipose derived stem cells (hADSCs). Methods for making the multifunctional biomaterials and their use in biological application are also provided.
Year: 2014
Country: WO
Doc No: 2014004651