23 Jul IMPLANT MADE OF A COMPOSITE MATERIAL WITH CONTROLLED POROSITY
Abstract
The invention relates to an implant material for filling bone defects, for bone regeneration and for bone tissue engineering, to an implant comprising this material, and to a method for producing such an implant. The implant material of the invention comprises a matrix of a composite material comprising: a bioactive glass M based on SiO2 and CaO, optionally containing P2O5 and/or optionally doped with strontium, and a biodegradable polymer P soluble in an aqueous medium and chosen from among the bioresorbable polysaccharides, preferably chosen from among dextran, hyaluronic acid, agar, chitosan, alginic acid, sodium or potassium alginate, galactomannan, carrageenan, pectin; the bioresorbable polyesters, preferably polyvinyl alcohol; the biodegradable synthetic polymers, preferably a polyethylene glycol; and proteins, preferably gelatin or collagen, and it consists of a matrix comprising at least the biodegradable polymer P, this matrix having at least 70% by number of pores having the shape of spheres or polyhedrons inscribed within a sphere, the diameter of the spheres being between 200 and 800 μm inclusive, with a deviation between the diameter of the smallest sphere and the largest being at most 30% with respect to the arithmetic mean diameter of all the spheres of the implant, and the interconnections between the pores having their smallest dimension between 25 μm and 250 μm inclusive, at least 70% by number of pores having at least one interconnection with another pore. The invention has an application in the medical field in particular.
Year: 2014
Country: WO
Doc No: 2014195862