23 Jul Preparation method of artificial esophagus with histological structure
Abstract
The invention discloses a preparation method of an artificial esophagus with histological structure. The method is characterized by comprising the steps of: extracting a basilemma membrane protein solution from animal esophageal mucosa tissue; then preparing electrospinning / acellular matrix bracket; then preparing a polyurethane sheet with a double-sided microgroove; and finally coating the polyurethane sheet on the electrospinning / acellular matrix bracket and splicing into a tube shape longitudinally, so as to obtain the artificial esophagus with histological structure. The invention has the advantage that the method can prepare the artificial esophagus simulating histological structure of normal human esophageal, and utilizes the principles of tissue engineering to construct in vitro the artificial esophagus with similar microstructure and function as human esophagus; and the artificial esophagus is seamed with residual esophagus after resection of lesion esophagus layer by layer, so that the artificial esophagus gradually grows into a real esophagus and integrates with the original esophagus in the human body. Compared with the traditional alternatives, the artificial esophagus has structure and function similar to those of natural esophagus, and can alleviate the suffering of patients and prolong the patient’s life.
Year: 2014
Country: CN
Doc No: 104013998