23 Jul Composite active bone cement containing sustained release drug-loading nanoparticles and preparation method of bone cement
Abstract
The invention discloses composite active bone cement containing sustained release drug-loading nanoparticles. The composite active bone cement comprises sustained release drug-loading nanoparticles and calcium phosphate bone cement, wherein the sustained release drug-loading nanoparticles comprise PEG-b-PLGA polymer drug carriers and hydrophobic medicines. The invention also discloses a method for preparing the composite active bone cement containing sustained release drug-loading nanoparticles. The preparation method comprises the following steps: by taking polyethylene glycol PEG as an initiator, carrying out a ring opening polymerization reaction, thereby obtaining a high-molecular polymer PEG-b-PLGA to serve as a drug carrier; preparing the drug-loading nanoparticles through a solvent volatilization method; and mixing the drug-loading nanoparticles with calcium phosphate bone cement powder, curing and forming, thereby obtaining the composite active bone cement. After the composite active bone cement provided by the invention is implanted into a patient, an eruption effect of the medicine can be reasonably reduced, slow release of the loaded medicines and long-term stabilization of the vertebral body of the patient are facilitated, and the composite active bone cement can serve as a composite tissue engineering scaffold for integrating bone repair and treatment.
Year: 2015
Country: CN
Doc No: 104288833