23 Jul Biodegradable physical hydrogel capable of being rapidly gelatinized in situ and preparation method of biodegradable physical hydrogel
Abstract
The invention relates to the technical field of biodegradable high-polymer materials, and aims at providing a biodegradable physical hydrogel capable of being rapidly gelatinized in situ and a preparation method of the biodegradable physical hydrogel. The biodegradable physical hydrogel capable of being rapidly gelatinized in situ is composed of a component A aqueous solution and a component B aqueous solution. The preparation method specifically comprises the following preparation steps: by taking stannous octoate as a catalyst, synthesising a component A and a component B through ring-opening polymerization respectively; dissolving the prepared component A and component B in water respectively, then mixing to form a mixed solution and carrying out an oscillation treatment to obtain a stable physical cross-linked hydrogel. The preparation process of the hydrogel disclosed by the invention is simple, and the gelatinization time and the mechanical strength of the hydrogel can be adjusted by changing the ratio of the component A to the component B and a total polymer concentration; the prepared hydrogel is biodegradable, capable of being metabolised by a human body, capable of being rapidly gelatinized in situ without external stimulation, and capable of being used in the biomedical fields of medicine carriers, tissue engineering and the like.
Year: 2015
Country: CN
Doc No: 104592727