23 Jul Microfluidic chip and method for establishing in-vitro co-culture model of three kinds of cells
Abstract
The invention relates to the field of micromachining technology and tissue engineering technology, and particularly relates to a microfluidic chip and method for establishing an in-vitro co-culture model of three kinds of cells. The microfluidic chip is used for establishing a co-culture model of three kinds of cells; different cells are located in different areas through connected micro-channels in the microfluidic chip; and two kinds of cells can conduct cell communication through the connected micro-channels. Therefore, through the scheme, a new model capable of connecting astrocyte as a middle bridge in a neurovascular unit with the neuron and microvascular endothelial cell in a three-dimensional or plane space is established in vitro, a neurovascular network in the brain can be reproduced in vitro more scientifically and really, and a better platform is provided for clinical basic research on the central nervous system diseases and particularly the blood vessels of brain; and meanwhile, as an emerging biochip, the microfluidic chip is used for establishing the neurovascular in vitro, and thus the application range of the microfluidic chip is further widened.
Year: 2015
Country: CN
Doc No: 104630059