23 Jul Making method of aggrecanases inhibitor combined with in-vitro cross-linked hyaluronic acid hydrogel and application thereof in drugs for treating osteoarthritis
Abstract
The invention discloses a making method of an aggrecanases inhibitor combined with in-vitro cross-linked hyaluronic acid hydrogel and application thereof in drugs for treating osteoarthritis. The making method comprises the steps of aldehyde group modification on hyaluronic acid, adipic dihydrazide modification on hyaluronic acid and in-vitro cross-linking of hyaluronic acid. The aggrecanases inhibitor combined with in-vitro cross-linked hyaluronic acid hydrogel provided by the invention has properties of sustained releasing drugs, can effectively alleviate rat osteoarthritis, promote expression of proteoglycan of osteoarthritis knees and inhibit expression of degradation products of proteoglycan. According to the making method of the aggrecanases inhibitor combined with the in-vitro cross-linked hyaluronic acid hydrogel and application thereof in drugs for treating osteoarthritis, biological materials and drugs are combined, a tissue engineering method is adopted for treating osteoarthritis, the manner of delivering drugs to articular cavities is utilized, wound caused by treatment of osteoarthritis is reduced, the sustained release drug delivery manner can improve local drug concentration while reducing corresponding side effect caused by systemic administration of drugs.
Year: 2015
Country: CN
Doc No: 104940944