23 Jul PROGENITOR CELLS FROM URINE AND METHODS FOR USING THE SAME
Abstract
PROBLEM TO BE SOLVED: To provide urine progenitor cells, and to provide a method for producing a culture of urine progenitor cells from a urine sample, for urological tissue engineering and cell therapy.SOLUTION: The cells may be selected based upon the use of a selective cell medium, based upon morphology, and/or by selecting cell-specific markers. The invention provides an isolated urine progenitor cell that is c-kit positive and can differentiate into urothelium, smooth muscle, endothelium or interstitial cells. The invention also provides methods of use of the urine progenitor cells, wherein the cells are seeded onto a tissue scaffold. The invention also provides methods of treating a subject in need thereof comprising providing a bladder tissue substrate that includes differentiated UPCs and transplanting the substrate into the patient. Finally, the invention provides kits that include a container suitable for the transport of a urine sample; media; one or more types of antibiotics; a package for holding the container, media, and antibiotics; and optionally, instructions for use.SELECTED DRAWING: Figure 1
Year: 2016
Country: JP
Doc No: 2016093181