23 Jul Biomimetic active peptide suitable for titanium-based medical material modified with one-step method
Abstract
The invention belongs to the field of biological materials for tissue engineering and particularly relates to a biomimetic active peptide suitable for a titanium-based medical material modified with a one-step method. The molecular structure of the biomimetic active peptide is divided into three parts, namely, a supporting part which is multiple DOPA amino acid sequences at one end, a spaced part which are spaced amino acid sequences in the middle and an active part which is polypeptide sequences with biological activity at the other end. The designed biomimetic active peptide can greatly overcome defects of a surface modification method of existing titanium-based medical biological materials. When the biomimetic active peptide is used for modifying the titanium-based medical biological material, complex modification steps are avoided, the titanium-based medical biological material with biological functionality can be prepared with the one-step method, and accordingly, the biomimetic active peptide has the advantages of simplicity, high efficiency, flexibility and selectivity of biological activity. More importantly, designed polypeptide molecules have a high biomemetic property and can be clinically popularized and used conveniently.
Year: 2016
Country: CN
Doc No: 105949322