23 Jul Bone tissue engineering scaffold with multi-scale controllable micropore structure and preparation method thereof
Abstract
The invention provides a bionic bone tissue engineering scaffold material and preparation method thereof, and the scaffold material has multi-level micropore structure similar to the natural bone tissue. The scaffold has multi-level bionic bone three-dimensional pore structure which can be adjusted in the range from 500 nm to 1000 mum. The preparation method of the bone tissue engineering scaffold with multi-scale controllable micropore structure includes performing three-dimensional printing with medical polymer material by using a rapid proto-typing technology, customizing the primary-level micrometer scale three-dimensional pore structure and the shape of the scaffold, and preparing the second-level micrometer and nanometer scale micropore inside of the scaffold by using supercritical gas foaming. The prepared bone tissue engineering scaffold with multi-scale micropore structure can provide the three-dimensional supporting needed by the bone tissue regeneration, can meet the requirements of protein adsorption, nutriment/metabolite transportation, cell migration, and tissue growing in different scales, and has wide application prospect in orthopedic clinic.
Year: 2016
Country: CN
Doc No: 105944147