23 Jul Reinforced ligament tissue engineering scaffold and preparation method for same
Abstract
The invention relates to a reinforced ligament tissue engineering scaffold and a preparation method for the same, and belongs to the technical field of medical equipment. The reinforced ligament tissue engineering scaffold consists of a reinforcement skeleton nested between adjacent electrospun nanofiber felt layers, the number of the electrospun nanofiber felt layers is at least three, a material for the electrospun nanofiber felt layers is a composite of silk fibroin and polyvinyl alcohol according to the mass ratio of 1/9 to 1/1, and the reinforcement skeleton is formed by at least two silk threads or absorbable sutures which are arranged in parallel along the length direction of the electrospun nanofiber felt layers. The scaffold is of a uniform and stable microstructure, and has high biocompatibility, a matrix condition is provided for growth of ligament tissues, and the requirements of keeping slow reduction in mechanical strength of the scaffold in a process of ingrowth of neonatal ligament tissues and slow degradation of nanofibers and stability of a connected joint are met. The preparation method for the scaffold is simple, convenient to operate and adapted to preparation of reinforced ligament tissue engineering scaffolds meeting different mechanical performance requirements.
Year: 2017
Country: CN
Doc No: 106474543