23 Jul Method of inducing fibroblasts into chondrocyte like cells
Abstract
The invention relates to a method for inducing fibroblasts into chondrocyte like cells, and belongs to the field of cell biology and regenerative medicine. The method aims at the general problems that carrier mediation and transgenic operation are needed, requirements on experimental facilities and technical level are relatively high, the security of produced chondrocytes is relatively poor and the like in methods for transdifferentiation of the fibroblasts into the chondrocytes in the prior art, and uses fish oocyte extract for inducing reprogramming of the fibroblasts into the chondrocyte like cells. The chondrocyte like cells are obtained only by use of the fish oocyte extract for inducing and use of a chondroblast induction medium for directional inducing culture without introduction of exogenous genes, so that experimental operation is relatively simple, and the obtained chondrocyte like cells are better in security, and have a broad application prospect in the field of cartilage tissue engineering and regenerative medicine.
Year: 2017
Country: CN
Doc No: 107267448