23 Jul Method for improving stability and biological activity of PLGA electrospun fiber membrane
Abstract
The invention provides a method for improving the stability and biological activity of a PLGA electrospun fiber membrane. The method includes the steps of adding CaCO3 into a PLGA solution, and then conducting electrospinning to prepare the composite PLGA electrospun fiber membrane; or heating a conventional PLGA electrospun fiber membrane at 40-50 DEG C, and then conducting cooling to normal temperature to obtain the heat-treated PLGA electrospun fiber membrane. The composite PLGA electrospun fiber membrane is prepared from composite CaCO3 and PLGA, or the heat-treated PLGA electrospun fibermembrane is obtained by conducting heat treatment on the conventional PLGA electrospun fiber membrane, so that under the premise of maintaining the original shape, the spatial stability of the PLGA electrospun fiber membrane is improved, the degradation rate of the PLGA electrospun fiber membrane is decreased, and the biological activity of a fiber stent prepared from the PLGA electrospun fiber membrane is further improved. The PLGA electrospun fiber membrane prepared by the method has good stability, good biological activity and a great application value in a long-term repair process of tissue engineering. In addition, the method is simple and can be implemented without large equipment.
Year: 2018
Country: CN
Doc No: 108560144