23 Jul Preparation method of polymer tissue engineering stent effectively loaded with heparin and polymer tissue engineering stent thereof
Abstract
The invention belongs to the field of tissue engineering stents, and discloses a preparation method of a polymer tissue engineering stent effectively loaded with heparin. The preparation method comprises the following steps of (1) dissolving a polymer into a good solvent, so as to prepare a polymer solution; (2) dissolving the heparin into a water-containing organic solvent mixed with the good solvent in step (1), so as to obtain a heparin solution; (3) uniformly mixing the polymer solution and the heparin solution to obtain a mixed electrostatic spinning solution, putting the mixed electrostatic spinning solution into an injector to perform electrostatic spinning, and receiving by a receiving device which rotates at high speed, so as to obtain the oriented-arrangement type polymer tissueengineering stent loaded with the heparin. The preparation method has the advantages that the spinnability of the mixed electrostatic spinning solution mixed by the heparin and the polymer is improved, the fiber film with good property can be formed, the content of the heparin in an anticoagulation medicine is increased, and the anticoagulation property of the stent is further improved. The invention also discloses the polymer tissue engineering stent loaded with the heparin prepared by the preparation method.
Year: 2019
Country: CN
Doc No: 109513049