23 Jul Shape memory-type bioactive nano particle/biodegradable polyester composite multi-scale pore biological scaffold and preparation method thereof
Abstract
The invention belongs to the technical field of biomedical materials, and discloses a shape memory-type bioactive nano particle/biodegradable polyester composite multi-scale pore biological scaffold and a preparation method thereof. The method of the invention comprises the steps of: adding biodegradable shape memory polyester, hydroxyapatite nano particles and a rheology modifier to an organic solvent, and performing ultrasonic effect to obtain an oil phase; adding water to the oil phase, and performing emulsification to form water-in-oil high-internal phase emulsion; and taking the high-internal phase emulsion as an ink, adopting extrusion-type 3D printing to obtain a three-dimensional porous emulsion scaffold, and evaporating the solvent to obtain the biological scaffold. The scaffold contains a multi-scale pore structure, in which controllable micropores and macropores coexist. The porosity is higher than 85%, and the pore structures are connected to one another, so that the scaffold has excellent biocompatibility, biodegradability, biological activity, shape memory effect, and drug growth/factor loading and release, and can be applied in the field of drug controlled release and the field of tissue engineering scaffolds.
Year: 2019
Country: CN
Doc No: 109701084