23 Jul Degradable polyurethane material with active oxygen responsiveness and preparation method of degradable polyurethane material
Abstract
The invention discloses a degradable polyurethane material with active oxygen responsiveness and a preparation method of the degradable polyurethane material. The degradable polyurethane material comprises a biodegradable polyester glycol soft segment and a hard segment composed of saturated aliphatic diisocyanate and reactive oxygen responsive small molecular diamine. The material is prepared bytaking poly(epsilon-caprolaclone glycol) (PCL) or polypropylene glycol fumarate (PPF) as macromolecular diols, saturated aliphatic diisocyanate as a raw material and reactive oxygen responsive small molecular diamine as a chain extender and adopting a two-step chain extension method. A polyurethane elastomer prepared from the degradable polyurethane material has good biocompatibility and responsiveness to reactive oxygen, the material and a degradation product are harmless to human bodies, so that the degradable polyurethane material can be widely applied to the fields such as biological medicines and tissue engineering and can be used for bone repair and myocardium generation.
Year: 2019
Country: CN
Doc No: 109988280