23 Jul Polyurethane material containing polythioketal soft segment and capable of being degraded with active oxygen, and preparation method thereof
Abstract
The invention relates to a polyurethane material containing a polythioketal soft segment and capable of being degraded with active oxygen, and a preparation method thereof, wherein the polyurethane material comprises a polythioketal soft segment and a saturated aliphatic diisocyanate hard segment. The preparation steps comprise: carrying out a reaction on excess bis(2-mercaptoethyl)ether and 2,2-dimethoxypropane to prepare polythioketal; carrying out a reaction on the polythioketal and diisocyanate or on the polythioketal, polyethylene glycol and diisocyanate, and carrying out one-pot additionto obtain a prepolymer; and carrying out a diol or diamine chain extension reaction to obtain polyurethane. According to the present invention, by using the one-pot method, the polythioketal or the polythioketal and the polyethylene glycol as the soft segment are polymerized into the polyurethane; the polyurethane obtained by copolymerizing with the polyethylene glycol has amphiphilicity, and thehydrophilic/hydrophobic chain segment ratio can be adjusted through the feeding ratio; and the polyurethane can be used for producing nanoparticles, tissue engineering scaffolds or hydrogels, and issuitable for physiological environments with high active oxygen content, and has good application prospects in the biomedical field.
Year: 2019
Country: CN
Doc No: 110183608