23 Jul 3D-printing PCL-isoniazide rifampicin streptomycin anti-bone tuberculosis bone tissue engineering scaffold, as well as preparation method and applications
Abstract
The invention provides a 3D-printing PCL-isoniazide rifampicin streptomycin anti-bone tuberculosis bone tissue engineering scaffold, as well as a preparation method and applications and belongs to thefield of medical implants in bioengineering. The scaffold is a tissue engineering scaffold material having a porous microstructure, wherein with poly-epsilon-caprolactone being a substrate and isoniazide streptomycin being an anti-tuberculosis medicine, the materials are heated to 100 DEG C and are liquefied by means of a heating system in a fusion press shaping type 3D printer; the materials aregradually cooled in an FDM technology extrusion channel, and meanwhile is blended with a solution, containing the anti-tuberculosis medicine, at a spinning port of the 3D printer; then the mixture isextruded to shape fiber bundles; by means of different splicing framework of the fiber bundles at different layers and angles, the product can be produced through steps of room temperature shaping at23 DEG C, drying, and ethylene oxide disinfection. The tissue engineering scaffold has simple and reliable structure, is controllable in shape and microstructure, has reliable mechanical performance,is controllable in medicine release property, is convenient to implant, is less in trauma and is low in cost.
Year: 2018
Country: CN
Doc No: 109010911