23 Jul 3D-printed bone tissue engineering scaffold with sustained-release antibacterial function and preparation method of scaffold
Abstract
The invention discloses a 3D-printed bone tissue engineering scaffold material with a sustained-release antibacterial function and a preparation method of the material. The scaffold material is formedby in-situ crosslinking of a porous calcium phosphate material and sodium alginate, and berberine is loaded at the same time. According to the bone tissue engineering scaffold material, berberine drugs are added into printing ink, so that the scaffold has the functions of resisting bacteria and promoting bone; and finally, the pore structure of the scaffold is regulated and controlled by a 3D printing and post-processing manner, the crosslinking degree of the scaffold is regulated and controlled by changing the concentration and crosslinking time of a calcium chloride crosslinking agent, andthe drug loading amount of the scaffold is regulated and controlled by changing the drug concentration to realize the drug slow release effect of the scaffold.
Year: 2019
Country: CN
Doc No: 109966547