23 Jul 3D printed biological scaffold with gene slow release effect, and preparation method and applications thereof
Abstract
The invention relates to a preparation method of a 3D printed biological scaffold with gene slow release effect. The preparation method comprises following steps: a water soluble polysaccharide containing amino groups and carboxyl groups and a DNA carrier capable of coding growth factors are uniformly mixed in water so as to obtain a mixed solution; a water soluble material is uniformly mixed witha biological scaffold material for 3D printing so as to obtain a 3D printed biological scaffold; the 3D printed biological scaffold is immersed into water so as to remove the water soluble material,and is subjected to surface modification with active groups; the 3D printed biological scaffold with the active groups on the surface is immersed in the mixed solution so as to obtain the 3D printed biological scaffold with gene slow release effect. The invention also provides the 3D printed biological scaffold with gene slow release effect prepared through the preparation method, and applicationsof the 3D printed biological scaffold with gene slow release effect as tissue engineering bone. The preparation method is simple; the 3D printed biological scaffold is capable of releasing growth factors slowly, adjusting and controlling cell expression effectively, and promoting bone restoration.
Year: 2018
Country: CN
Doc No: 108452373